Itachi Uchiha Vs Madoka Orimura Itachi uchiha and nagato w six paths vs edo madaraitachi and pain are in their prime and are not sick itachi also has shisui s eyeedo madara specal c

He s immune to normal genjutsu to an extent and has created most of the if it is itachi in his prime vs tobirama in his prime i give tobirama the win 6 5 10